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Luís Quecedo y Juan del Llano de la Fundación Gaspar Casal presentan su contribución al "International Society for Pharmacoeconomics and Outcomes Research 14th Annual European Congress, 5-8 Madrid"

Éstos son los resúmenes de las dos presentaciones:
SYSTEMATIC REVIEW OF STUDIES OF THE EFFICIENCY OF NEGATIVE PRESSURE THERAPY FOR COMPLEX FOOT WOUNDS IN DIABETIC PATIENTS
Quecedo L, Del Llano J
Fundación Gaspar Casal, Madrid, Spain
OBJECTIVES: Systematic analysis of the available studies of the clinical effectiveness and safety of negative pressure therapy, as compared with traditional courses of treatment, in complex foot wounds in diabetic patients. METHODS: A bibliographical search was performed in the following databases: Embase.com, Medline and Cochrane Library, covering from 2000 until the present. The following descriptors and key words were used: diabetic foot, negative-pressure wound, vacuum-assisted closure and diabetic ulcers. The Jaddad criteria were used to determine the quality of the clinical trials. The studies selected were randomized clinical trials that featured patients older than 18 years, with complex ulcers, postoperative wounds, or wounds resulting from the amputation of the foot, with a control group comparing negative pressure therapy with conventional therapies (salive solution, alginates or hydrophilic substances. The treatments were applied every 48 hours. A total of 12 studies, of which only 7 were pertinent, were selected. Two independent reviewers extracted the information and determined the methodological quality of the selected studies. RESULTS: Of the 7 studies selected (539 patients), 5 involved patients with postoperative wounds and 2 used the same group of patients. One of the two studies involving ulcers of the foot was limited by its simple size (N=10). The methodological quality of the studies is moderate-low. CONCLUSIONS: The evidence supports the effectiveness and security of negative pressure wound therapy in complex foot ulcers in diabetic patients. Given that it is unlikely that further research will change this positive appraisal (despite the moderate-low quality of the studies analyzed, its cost profile and the absence of adverse effects) it is possible to make a strong recommendation in favor of the therapy.
REVIEW OF ECONOMIC ASSESSMENTS OF EMERGING GENOMIC TECHNOLOGIES IN ONCOLOGY
Quecedo L, Del Llano J
Fundación Gaspar Casal, Madrid, Spain
OBJECTIVES: A systematic review of the economical assessment studies on genomics and proteomics in the field of oncology. Our aim is to analyze those emerging diagnostic and therapeutic technologies whose cost effectiveness ratio make them suitable for its adoption in the different health systems from a social point of view. METHODS: We locate the most relevant studies in the last 10 years in Medline, Embase, Cancerlit, Cochrane Library databases and we analyze the results. The following keywords were used: genetic screening, gene, pharmacogenomics, proteonomics, microarrays, biochips, cost analysis, cost effectiveness, cost benefit, cost minimization, neoplasm, tumour and cancer. RESULTS: We analyze 13 studies from which 5 assess aspects about breast cancer, 7 about colorectal neoplasm, and 1 about urologic pathology. From these analyzed studies, 4 were cost utility studies, 8 were cost effectiveness studies, and one was a cost minimization study. CONCLUSIONS: We highlight the increase of economical assessment studies on genomics and proteomics, constituting an invaluable help for the sanitary and medical decision makers over the suitability and relevance of incorporating the contributions of genomics and proteomics in the field of oncology, introducing the specific ethical and social aspects of this specialty.


Madrid, lunes, 07 de noviembre de 2011

Leer noticia completa: http://www.fgcasal.org/fgcasal/database/noticias/14ispor.pdf

 


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